FP7 logo euThe SATURN project has received funding from the European Community's Seventh Framework Programme [FP7/2007-2013] under grant agreement n°241796

Impact of Specific Antibiotic Therapies on the Prevalence of Human Host Resistant Bacteria

Partners: Universität Würzburg – (UW)

The organisation

UWThe Institute for Molecular Biology of Infectious Diseases is part of the Medical and Biological Faculties of the University of Würzburg (Germany). The research activities of the Institute are focused on the molecular characterisation of pathogenic bacteria, the analysis of host-pathogen interactions, the expression of virulence genes, the transfer of resistance determinants and the development of diagnostic tools for the detection of pathogenic micro-organisms. Dr. Dobrindt is head of a research group working in the field of comparative genomics, expression profiling, molecular epidemiology and proteomics of pathogenic and non-pathogenic E. coli. Using different ExPEC model strains, we successfully contributed to the characterisation of single factors and mechanisms involved in pathogenesis, fitness and adaptation of extraintestinal pathogenic E. coli (ExPEC) and intestinal pathogenic E. coli (IPEC) including biofilm formation, adhesion, invasion, microcins, fimbriae, siderophore systems (aerobactin, salmochelin and yersiniabactin) and toxins (alpha-hemolysin, cytotoxic necrotising factor, cytolethal distending toxin and colibactin). Dr. Ohlsen is heading a research group working with staphylococci. He has a long-term experience in molecular biology of staphylococci including the generation of knock out and conditional mutants, investigation of resistance gene transfer, the use of reporter genes, the investigation of biofilms, transcriptome and proteome analysis, virulence characterisation and the use of animal models.

Key staff involved in the project

Ulrich DobrindtUlrich Dobrindt, Dr., study of biology at University of Göttingen, 1999 PhD (Microbiology) University of Würzburg, 1999-2000 Post-doctoral fellow; Institute for Molecular Infection Biology, University of Würzburg 2000 Group leader (E. coli Pathogenomics), Institute for Molecular Infection Biology, University of Würzburg 2006. Habilitation in Microbiology Evolution and virulence mechanisms of pathogenic and non-pathogenic Enterobacteriaceae, genetic structure of pathogenicity and genomic islands of E. coli, characterisation of traits of commensal E. coli, molecular biology of E. coli virulence factors including polyketide biosynthesis, siderophore systems, adhesins, secretion systems, gene regulation.

Knut OhlsenKnut Ohlsen, Dr., study of biology at University of Leipzig, 1998 PhD (Microbiology) University of Würzburg, 1998-2002 Post-doctoral fellow; Institute for Molecular Infection Biology, University of Würzburg 2002 Group leader (Staphylococci), Institute for Molecular Infection Biology, University of Würzburg 2008 Habilitation in Microbiology, Fitness and virulence mechanisms of pathogenic staphylococci, animal models, gene regulation, trancriptome studies, gene transfer in vitro and in vivo.

Tina Schäfer, Dr. study of biology at University of Würzburg, 2010 PhD (Microbiology), Development of in vivo models to assess Staphylococus aureus virulence mechanisms, introduction of bioluminescence-based in vivo imaging technology.

Further information

www.infektionsforschung.uni-wuerzburg.de

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