FP7 logo euThe SATURN project has received funding from the European Community's Seventh Framework Programme [FP7/2007-2013] under grant agreement n°241796

Impact of Specific Antibiotic Therapies on the Prevalence of Human Host Resistant Bacteria

Scientific publications


Adler A, Hussein O, Ben-David D, Masarwa S, Navon-Venezia S, Schwaber MJ, Carmeli Y; Post-Acute-Care Hospital Carbapenem-Resistant Enterobacteriaceae Working Group "Persistence of Klebsiella pneumoniae ST258 as the predominant clone of carbapenemase-producing Enterobacteriaceae in post-acute-care hospitals in Israel, 2008-13". J Antimicrob Chemother. 2015 Jan;70(1):89-92. doi: 10.1093/jac/dku333. Epub 2014 Sep 8


Lerner A, Adler A, Abu-Hanna J, Cohen Percia S, Kazma Matalon M, Carmeli Y "Spread of KPC-producing carbapenem-resistant Enterobacteriaceae: the importance of super-spreaders and rectal KPC concentration". Clin Microbiol Infect. 2014 Dec 26. pii: S1198-743X(14)00168-2. doi: 10.1016/j.cmi.2014.12.015. [Epub ahead of print]

Vervoort J, Xavier BB, Stewardson A, Coenen S, Godycki-Cwirko M, Adriaenssens N, Kowalczyk A, Lammens C, Harbarth S, Goossens H, Malhotra-Kumar S. "An in vitro deletion in ribE encoding lumazine synthase contributes to nitrofurantoin resistance in Escherichia coli". Antimicrob Agents Chemother. 2014 Dec;58(12):7225-33. doi: 10.1128/AAC.03952-14. Epub 2014 Sep 22

Roca I, Mosqueda N, Altun B, Espinal P, Akova M, Vila J "Molecular characterization of NDM-1-producing Acinetobacter pittii isolated from Turkey in 2006". J Antimicrob Chemother. 2014 Dec;69(12):3437-8. doi: 10.1093/jac/dku306. Epub 2014 Aug 4

Vergara A, Zboromyrska Y, Mosqueda N, Morosini MI, García-Fernández S, Roca I, Cantón R, Marco F, Vila J. "Evaluation of a loop-mediated isothermal amplification-based methodology to detect carbapenemase carriage in Acinetobacter clinical isolates". Antimicrob Agents Chemother. 2014 Dec;58(12):7538-40. doi: 10.1128/AAC.03870-14. Epub 2014 Sep 15

Stewardson AJ, Gaïa N, François P, Malhotra-Kumar S, Delémont C, Martinez de Tejada B, Schrenzel J, Harbarth S, Lazarevic V; for the SATURN WP1 and WP3 Study Groups "Collateral damage from oral ciprofloxacin versus nitrofurantoin in outpatients with urinary tract infections: a culture-free analysis of gut microbiota". Clin Microbiol Infect. 2014 Nov 25. pii: S1198-743X(14)00102-5. doi: 10.1016/j.cmi.2014.11.016. [Epub ahead of print]

Adler A, Miller-Roll T, Assous MV, Geffen Y, Paikin S, Schwartz D, Weiner-Well Y, Hussein K, Cohen R, Carmeli Y "A multicenter study of the clonal structure and resistance mechanism of KPC-producing Escherichia coli isolates in Israel". Clin Microbiol Infect. 2014 Oct 29. pii: S1198-743X(14)00070-6. doi: 10.1016/j.cmi.2014.10.008. [Epub ahead of print]

Temkin E, Adler A, Lerner A, Carmeli Y "Carbapenem-resistant Enterobacteriaceae: biology, epidemiology, and management". Ann N Y Acad Sci. 2014 Sep;1323:22-42. doi: 10.1111/nyas.12537

Roca I, Mosqueda N, Altun B, Espinal P, Akova M, Vila J "Molecular characterisation of NDM-1-producing Acinetobacter pitti isolated from Turkey in 2006". J. of Antimicrobial Chemotherapy, August 4, 2014, doi: 10.1093/jac/dku306

van Duijn PJ, Bonten MJ "Antibiotic rotation strategies to reduce antimicrobial resistance in Gram-negative bacteria in European intensive care units: study protocol for a cluster-randomized crossover controlled trial". Trials, 2014 Jul 10;15, 277, doi: 10.1186/1745-6215-15-277

Vervoort J, Gazin M, Kazma M, Kotlovsky T, Lammens C, Carmeli Y, Goossens H, Malhotra-Kumar S "High rates of intestinal colonisation with fluoroquinolone-resistant ESBL-harbouring Enterobacteriaceae in hospitalised patients with antibiotic-associated diarrhoea". European Journal of Clinical Microbiology & Infectious Diseases, July 2014.

Chmelnitsky I, Shklyar M, Leavitt A, Sadovsky E, Navon-Venezia S, Ben Dalak M, Edgar R, Carmeli Y "Mix and match of KPC-2 encoding plasmids in Enterobacteriaceae-comparative genomics". Diagn Microbiol Infect Dis, 2014 Jun, P 255-60, doi: 10.1016/j.diagmicrobio.2014.03.008

Xavier BB, Vervoort J, Stewardson A, Adriaenssens N, Coenen S, Harbarth S, Goossens H, Malhotra-Kumar S "Complete Genome Sequences of Nitrofurantoin-Sensitive and -Resistant Escherichia coli ST540 and ST2747 Strains". Genome Announc 2014 Apr 10;2(2) pii: e00239-14, doi: 10.1128/genomeA.00239-14

Huedo P, Yero D, Martínez-Servat S, Estibariz I, Planell R, Martínez P, Ruyra A, Roher N, Roca I, Vila J, Daura X, Gibert I "Two Different Rpf Clusters Distributed Among a Population of Stenotrophomonas Maltophilia Clinical Strains Display Differential DSF Production and Virulence Regulation". Journal of Bacteriology, 25 April 2014, 196(13), 2431-2442, doi: 10.1128/JB.01540-14

Stewardson AJ, Renzi G, Maury N, Vaudaux C, Brossier C, Fritsch E, Pittet D, Heck M, van der Zwaluw K, Reuland EA, van de Laar T, Snelders E, Vandenbroucke-Grauls C, Kluytmans J, Edder P, Schrenzel J, Harbarth S "Extended-spectrum β-lactamase-producing Enterobacteriaceae in hospital food: a risk assessment". Infect Control Hosp Epidemiol. 2014 Apr;35(4):375-83. doi: 10.1086/675609.

Muller AE, Punt N, Mouton JW "Exposure to ceftobiprole is associated with microbiological eradication and clinical cure in patients with nosocomial pneumonia". Antimicrob Agents Chemother. 2014 May;58(5):2512-9. doi: 10.1128/AAC.02611-13. Epub 2014 Feb 10.

Adler A, Assous MV, Paikin S, Shulman A, Miller-Roll T, Hillel S, Aronov R, Carmeli Y and Schwaber MJ "Emergence of VIM-producing Aeromonas caviae in Israeli hospitals". J. Antimicrob. Chemother. (2014) 69 (5): 1211-1214. doi: 10.1093/jac/dkt505 First published online: January 2, 2014.


Adler A, Khabra E, Chmelnitsky I, Giakkoupi P, Vatopoulos A, Mathers AJ, Yeh AJ, Sifric CD, Angelis G de, Tacconelli E, Villegas MV, Quinn J, Carmeli Y "Development and validation of a multiplex PCR assay for identification of the epidemic ST-258/512 KPC-producing K. pneumoniae clone". Diagnostic Microbiology and Infectious Disease (Oct. 2013). http://dx.doi.org/10.1016/j.diagmicrobio.2013.10.003.

Mosqueda N, Espinal P, Cosgaya C, Viota S, Plasensia V, Álvarez-Lerma F, Montero M, Gómez J, Horcajada JP, Vila J, Roca I "Globally Expanding Carbapenemase Finally Appears in Spain: Nosocomial Outbreak of Acinetobacter Baumannii Producing Plasmid-Encoded OXA-23 in Barcelona, Spain". Antimicrobial Agents and Chemotherapy, 57 (10), October 2013, pp 5155-5157, doi: 10.1128/AAC.01486-13

Adler A, Solter E, Masarwa S, Miller-Roll T, Abu-Libdeh B, Khammash H, Najem K, Dekadek S, Stein-Zamir C, Nubani N, Kunbar A, Assous MV, Carmeli Y, Schwaber MJ "Epidemiological and microbiological characteristics of an outbreak 1 caused by OXA-48-producing Enterobacteriaceae in a neonatal 2 intensive care unit in Jerusalem". J. Clin. Microbiol. 26 June 2013, P 2926-30, doi:10.1128/JCM.01049-13

Muller AE, Schmitt-Hoffmann AH, Punt N, Mouton JW "Monte Carlo simulations based on phase 1 studies predict target attainment of ceftobiprole in nosocomial pneumonia patients: a validation study". Antimicrob Agents Chemother. 2013 May;57(5):2047-53. doi: 10.1128/AAC.02292-12.

Schechner V, Kotlovsky T, Kazma M, Mishali H, Schwartz D, Navon-Venezia S, Schwaber MJ, Carmeli Y "Asymptomatic rectal carriage of blaKPC producing carbapenem-resistant Enterobacteriaceae: who is prone to become clinically infected?". Clin Microbiol Infect. 2013 May;19(5):451-6. doi: 10.1111/j.1469-0691.2012.03888.x.

Schechner V, Temkin E, Harbarth S, Carmeli Y, Schwaber MJ "Epidemiological interpretation of studies examining the effect of antibiotic usage on resistance". Clin Microbiol Rev, 2013 Apr; 26(2):289-307, doi: 10.1128/CMR.00001-13

Muller AE, Punt N, Mouton JW "Optimal exposures of ceftazidime predict the probability of microbiological and clinical outcome in the treatment of nosocomial pneumonia". J. Antimicrob. Chemother., April 2013, 68(4):900-6. doi: 10.1093/jac/dks468.

Macedo-Viñas M, De Angelis G, Rohner P, Safran E, Stewardson A, Fankhauser C, Schrenzel J, Pittet D, Harbarth S "Burden of meticillin-resistant Staphylococcus aureus infections at a Swiss University hospital: excess length of stay and costs". J. Journal of Hospital Infection 84, 19 April 2013, pp 132 – 137. doi: 10.1016/j.jhin.2013.02.015.

Feldman N, Adler A, Molshatzki N, Navon-Venezia S, Khabra E, Cohen D, Carmeli Y "Gastrointestinal Colonization by KPC-Producing Klebsiella pneumoniae Following Hospital Discharge: Duration of Carriage and Risk Factors for Persistent Carriage". Clin Microbiol Infect. 2013 Apr;19(4):E190-6. doi: 10.1111/1469-0691.12099.

Geffen Y, Adler A, Paikin S, Khabra E, Gorenshtein S, Aronov R, Carmeli Y "Detection of the plasmid-mediated KPC-2 carbapenem-hydrolysing enzyme in three unusual species of the Enterobacteriaceae family in Israel". J Antimicrob Chemother. 2013 Mar;68(3):719-20. doi: 10.1093/jac/dks443.

Lerner A, Romano J, Chmelnitsky I, Navon-Venezia S, Edgar R, Carmeli Y "Rectal Swabs Are Suitable for Quantifying the Carriage Load of KPC-Producing Carbapenem-Resistant Enterobacteriaceae". Antimicrob Agents Chemother. 2013 Mar;57(3):1474-9. doi: 10.1128/AAC.01275-12.

Stewardson A, Fankhauser C, De Angelis G, Rohner P, Safran E, Schrenzel J, Pittet D, Harbarth S "Burden of Bloodstream Infection Caused by Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae Determined Using Multistate Modeling at a Swiss University Hospital and a Nationwide Predictive Model". J. Infect Control Hosp Epidemiol. 2013 Feb;34(2):133-43. doi: 10.1086/669086.

Chmelnitsky I, Shklyar M, Hermesh O, Navon-Venezia S, Edgar R, Carmeli Y "Unique genes identified in the epidemic extremely drug-resistant KPC-producing Klebsiella pneumoniae sequence type 258". J Antimicrob Chemother. 2013 Jan;68(1):74-83. doi: 10.1093/jac/dks370.

Lerner A, Adler A, Abu-Hanna J, Meitus I, Navon-Venezia S, Carmeli Y "Environmental contamination by carbapenem-resistant Enterobacteriaceae (CRE)". J Clin Microbiol. 2013 Jan;51(1):177-81. doi: 10.1128/JCM.01992-12.


Afshari A, Pagani L, Harbarth S "Year in review 2011: Critical Care – infection". Crit Care. 2012 Dec 10;16(6):242.

Chmelnitsky I, Doniger T, Shklyar M, Naparstek L, Banin E, Edgar R, Carmeli Y "Draft genome sequence of an extremely drug resistance KPC-producing Klebsiella pneumoniae ST258 epidemic strain". J Bacteriol. 2012 Nov;194(21):6014. doi: 10.1128/JB.01546-12.

Adler A, Paikin S, Sterlin Y, Glick J, Edgar R, Aronov R, Schwaber MJ, Carmeli Y "A Swordless Knight: the epidemiology and molecular characteristics of the blaKPC-negative sequence-type 258 Klebsiella pneumoniae clone". J Clin Microbiol. 2012 Oct;50(10):3180-5. doi: 10.1128/JCM.00987-12.

Aldeyab MA, Harbarth S, Vernaz N, Kearney MP, Scott MG, Darwish Elhajji FW, Aldiab MA, McElnay JC "The impact of antibiotic use on the incidence and resistance pattern of extended-spectrum beta-lactamase-producing bacteria in primary and secondary healthcare settings". Br J Clin Pharmacol. 2012 Jul;74(1):171-9. doi: 10.1111/j.1365-2125.2011.04161.x.

Vervoort J, Baraniak A, Gazin M, Sabirova J, Lammens C, Kazma M, Grabowska A, Izdebski R, Carmeli Y, Kumar-Singh S, Gniadkowski M, Goossens H, Malhotra-Kumar S "Characterization of Two New CTX-M-25-Group Extended-Spectrum ß-Lactamase Variants Identified in Escherichia coli Isolates from Israel". PLoS ONE 7(9): e46329. doi:10.1371/journal.pone.0046329.

Naparstek L, Carmeli Y, Chmelnitsky I, Banin E, Navon-Venezia S "Reduced susceptibility to chlorhexidine among extremely-drug-resistant strains of Klebsiella pneumoniae". J Hosp Infect. 2012 May;81(1):15-9. doi: 10.1016/j.jhin.2012.02.007.

Gazin M, Paasch F, Goossens H, Malhotra-Kumar S "Current Trends in Culture-Based and Molecular Detection of Extended-Spectrum-ß-Lactamase-Harboring and Carbapenem-Resistant Enterobacteriaceae". J Clin Microbiol. 2012 Apr;50(4):1140-6. doi: 10.1128/JCM.06852-11.

De Angelis G, Restuccia G, Venturiello S, Cauda R, Malhotra-Kumar S, Goossens H, Schrenzel J, Tacconelli E "Nosocomial acquisition of methicillin-resistant Staphyloccocus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL) Enterobacteriaceae in hospitalised patients: a prospective multicenter study". BMC Infect Dis. 2012 Mar 29;12:74. doi: 10.1186/1471-2334-12-74.

Harbarth S, Samore MH "Clostridium: Transmission difficile?". PLoS Med 9(2): e1001171. doi:10.1371/journal.pmed.1001171.


Adler A, Shklyar M, Schwaber MJ, Navon-Venezia S, Dhaher Y, Edgar R, Solter E, Benenson S, Masarwa S, Carmeli Y "Introduction of OXA-48-producing Enterobacteriaceae to Israeli hospitals by medical tourism". J. Antimicrob. Chemother. (2011). doi: 10.1093/jac/dkr382.

Adler A, Navon-Venezia S, Moran-Gilad J, Marcos E, Schwartz D, and Carmeli Y "Laboratory and Clinical Evaluation of Screening Agar Plates for the Detection of Carbapenem-Resistant Enterobacteriaceae from Surveillance Rectal Swabs". J. Clin. Microbiol. June 2011 vol. 49 no. 6 2239-2242. doi: 10.1128/JCM.02566-10.

Schechner V, Kotlovsky T, Tarabeia T, Kazma M, Schwartz D, Navon-Venezia S, Carmeli Y "Predictors of Rectal Carriage of Carbapenem-Resistant Enterobacteriaceae (CRE) among Patients with Known CRE Carriage at Their Next Hospital Encounter". Infect Control Hosp Epidemiol. 2011 May;32(5):497-503. doi: 10.1086/659762.

Vernaz N, Huttner B, Muscionico D, Salomon JL, Bonnabry P, Lopez-Lozano JM, Beyaert A, Schrenzel J, Harbarth S "Modelling the impact of antibiotic use on antibiotic-resistant Escherichia coli using population-based data from a large hospital and its surrounding community". J. Antimicrob. Chemother. (2011). doi: 10.1093/jac/dkq525.


Leavitt A, Chmelnitsky I, Carmeli Y, Navon-Venezia S "Complete Nucleotide Sequence of KPC-3-Encoding Plasmid pKpQIL in the Epidemic Klebsiella pneumoniae Sequence Type 258". Antimicrob. Agents Chemother. October 2010 vol. 54 no. 10 4493-4496. doi: 10.1128/AAC.00175-10.

Leavitt A, Carmeli Y, Chmelnitsky I, Goren MG, Ofek I, Navon-Venezia S "Molecular Epidemiology, Sequence Types, and Plasmid Analyses of KPC-Producing Klebsiella pneumoniae Strains in Israel". Antimicrob Agents Chemother. 2010 Jul;54(7):3002-6. doi: 10.1128/AAC.01818-09.

Goren MG, Carmeli Y, Schwaber MJ, Chmelnitsky I, Schechner V, Navon-Venezia S "Transfer of Carbapenem-Resistant Plasmid from Klebsiella pneumoniae ST258 to Escherichia coli in Patient". Emerg Infect Dis. 2010 Jun;16(6):1014-7. doi: 10.3201/eid1606.091671.

Goren MG, Navon-Venezia S, Chmelnitsky I, Carmeli Y "Carbapenem-Resistant KPC-2-Producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008". Antimicrob Agents Chemother. 2010 Jun;54(6):2687-91. doi: 10.1128/AAC.01359-09.

Muras M "Antybiotykoterapia na cenzurowanym". Panaceum No 4 (152), April 2010 pp.15.

Gdycki-Cwirko M, Muras M, Kowalczyk A "Badanie wplywu swoistych sposobow leczenia antybiotykami na czestosc wystapienia opornych bakterii u nosicieli". Bulletin of the Medical University of Lodz No 2, February 2010 pp. 25-26.

Top ^